Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds

Nucleic Springform Pans acids are useful for biomedical targeting and sensing applications in which the molecular environment is different from that of a dilute aqueous solution.In this study, the influence of various types of mixed solutions of water and water-soluble organic compounds on RNA was investigated by measuring the catalytic activity of

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Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

HIV-1 particles assemble and bud from the plasma membrane of infected T lymphocytes.Infected macrophages, in contrast, accumulate particles within an apparent Cutout Thermostat intracellular compartment known as the virus-containing compartment or VCC.Many aspects of the formation and function of the VCC remain unclear.Here we demonstrate that VCC

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